Spectroscopic Studies of Triton X-114 and Quercetin/Rutin Solutions

Flavonoids belong to a large group of natural polyphenol compounds and have a broad spectrum of pharmacological activities. Many natural flavonoids are characterized by extremely low solubility in aqueous media and body fluids. To improve the solubility of drugs, various methods were developed and are used in pharmaceutics: solubilization, preparation of solid disperse systems with soluble and insoluble matrices, inclusion in liposomes, nanocapsules, and others [1]. Previously it was found that the solubility of the flavonoids quercetin and rutin increases substantially in the aqueous solutions of β-cyclodextrin, biopolymers, polyvinyl pyrrolidone and human serum albumin due to the formation of supramolecular complexes and that the spectral and protolytic properties of flavonoids in these organized media also change. Another type of organized media are self organized supramolecular micellar systems based on surfactants in which the solubility of hydrophobic substances can increase substantially due to solubilization [2]. Thus the purpose of the presented studies was to determine the interactions between the nonionic surfactant, Triton X-114 (TX114) micelles (C=8x104-8x10-3M) and quercetin as well as between the surfactant and quercetin glycoside, rutin (quercetin and rutin concentration C1=2x10, 4x10-5 and 6x10-5M) by spectroscopic methods at 293K. Results and Discussion